SUCCINATE BUFFER

IDENTIFICATION AND USE: a buffer that keeps the pH of a solution constant by taking up protons that are released during reactions, or by releasing protons when they are consumed by reactions. The observation that partially neutralized solutions of weak acids or bases are resistant to changes in pH when small amounts of strong acids or bases are added led to the concept of the ‘buffer’. Succinate buffer is prepared by dissolving succinic acid in distilled water. The pH of the buffer is adjusted with 0.2N sodium hydroxide.

FOUND IN THE FOLLOWING VACCINES: PNEUMOCOCCAL (PCV13- PREVNAR)