IDENTIFICATION AND USE: Hydrolyzed Collagen refers to enzymatically or chemically processed collagen derived from marine life, though it can also be taken from bovine, ox, pig skin, and bone. It is water soluble and contains peptides like amino acids as well as glycine, proline, hydroxyproline, and glutamic acid. Hydrolyzed collagen is normally used to benefit nails and skin due to the presence of the amino acids. It is also used to regenerate cells for the body’s lean muscle mass, benefit arthritis, and even help the body burn off fat and enhance weight loss.

HUMAN EXPOSURE AND TOXICITY: There is no documented evidence of a deleterious nature to humans from the ingestion of collagen, other than a rare allergenic response, when the diet has provided an adequate amount of the amino acid tryptophan and is deficient in several others, and thus is of low nutritive value.

ANIMAL STUDIES: Collagen is used in various pharmaceutical formulations. The incidence of tumors in experimental animals (mice) injected subcutaneously with gelatin in various strength solutions, did not differ from that in untreated control animals.

ADVERSE EFFECTS: Hydrolyzed collagen side effects from topical use may trigger dermatitis or inflammation of the skin. Initially, a mild rash may develop. Since dermatitis is an allergic reaction, the reaction may therefore depend on the person using the cream and doesn’t affect every user. Before taking any supplement orally, you should check with your physician for any allergies to animal products. While marine collagen is very much safe, people might have allergic reactions to animal or plant hydrolyzed collagen. Some hydrolyzed collagen supplements are now being made from chicken. While no studies yet show any bad effects from chicken based hydrolyzed collagen, other chicken based supplements aside from collagen have been known to cause mild cases of nausea, heartburn, diarrhea, constipation, drowsiness, skin reactions, and headache. No significant adverse findings other than rare hypersensitivity have been found in the examination of data from feeding and biochemical experiments.


  • Runny nose. Those who have collagen allergy can suffer from a runny nose after exposure or consumption of products that contain collagen
  • Hives. One of the most common reactions to collagen is hives
  • Diminished blood pressure level
  • Anaphylaxis