HEMIN CHLORIDE

IDENTIFICATION AND USE: Used in the management of porphyria attacks, particularly in acute intermittent porphyria. It may also be used for other conditions as determined by your doctor. Hemin is an enzyme inhibitor made from red blood cells. It works by correcting certain types of heme deficiency in the liver. Iron deficiency induces heme deficiency and anemia due to the lack of iron for ferrochelatase to incorporate into protoporphyrin IX. Iron deficiency is present in ∼ 2 billion women and children and causes oxidative damage and loss of function in mitochondria and mitochondrial DNA

HUMAN EXPOSURE AND TOXICITY: May cause mild fever; pain, redness, or swelling at the injection site. Seek medical attention right away if any of these severe side effects occur: Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); change in the amount of urine; unusual bleeding; unusual tiredness.

Hemin chloride, a heme oxygenase 1 inducer, is a porphyrin complex that is derived from erythrocytes. At a concentration of 20 mM Hemin chloride demonstrated the significance of heme in myotube maturation by increasing size, number, cross-striations, and contraction frequency and strength of myotubes.

The compound has been observed to induce cGMP formation through induction of guanylate cyclase. Hemin chloride has been noted to stimulate calcium-dependent K+ channels and modulate fluid transport and Na+ in the loop of Henle in rat studies. Hemin has also been documented to give rise to active chloride secretion in Caco-2 cells. In cadmium injured rat testes, hemin chloride demonstrated anti-apoptotic, anti-inflammatory and antioxidant properties. Derived from procine. Porcine: Having to do with swine. From the Latin “porcus” meaning “pig.” Historically, Porcine insulin is obtained from pig pancreas. A porcine skin graft is one in which pig skin is used, such as in surgical treatment of burns or other serious skin injuries.

FOUND IN THE FOLLOWING VACCINES: HIB + HEP B (COMVAX)